Immunohistochemically, strong expression of nuclear and cytoplasmic S100 protein, SOX 10 in virtually all cell nuclei, and also a marked expression of HMB45 at the cytoplasmic level of very many cells. Melan A is expressed by many cells (Figure 4). The histological and immunohistochemical analysis was in favor of melanoma. An assessment to search for primary melanoma was carried out: Ophthalomological examination, recto-sigmoidoscopy, esophagogastroduodenoscopy, nasofibroscopy, thoraco-abdominopelvic tomography were without abnormalities. The case of patient was discussed in a multidisciplinary consultation meeting, the tumor is considered unresectable. The therapeutic decision was to do palliative chemotherapy such as Carboplatin AUC2- Paclitaxel 80 mg/m2 D1D8D1=D21 given the deteriorated general condition of the patient. The patient received two cycles of chemotherapy with no clinical response with clear tumor progression. She died a week after the last course of chemotherapy. Overall survival was 10 weeks.