Antibacterial Activity of a Cyanobacterium Tolypothrix fragilis
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Telomere abrasion is considered a seal of the ageing process. Significant progresses have been made in understating the basic biology of telomere function through in vitro research, the rendition of this research to an in vivo perspective is limited. Though numerous techniques are there to label telomeres, most of these are toxic to cells and cause DNA damage or non-compatible for in vivo applications. The CRISPR-Cas system has enabled the refinement of these regions by fusing Cas9 to a fluorescent protein, allowing telomeres to be visualised in living organism. The success rate of CRISPR Cas 9 technique is a new promise for future genome editing therapeutics. Telomere length and rate of telomere shortening are directly related to aging and eventual death for any organism. This effect can potentially be reversed by increasing the telomere length of an organism. CRISPR Cas system is an effective tool that can be used in the insertion of telomeres in the DNA of any given organism without error. An infectious disease is one of the reasons for increasing number of deaths in developing countries and world-wide. They hold the second position after heart diseases. The search for antibiotics began in the late 1800s; the scientist began to devote time for searching the drugs that would kill the disease-causing bacteria. The goal of such research was to find so called ‘magic bullet or wonder drug’ that would destroy microbes without toxicity to the person taking that drug. Today, most of the diseases are caused by pathogens that can be cured with the help of available antibiotics. Still there is need to explore and develop new effective antibiotics against microbial pathogens because of resistance mechanism of the target organism. Taking this into consideration, there has been a global attention towards finding new chemicals, which led to the development of structure, which either directly or after some modifications can be used for development of new drugs.