Solanum is a large genus of flowering and fruiting plants, which include food crops of high economic importance, the potato, the tomato and the eggplant and others. It also contains the nightshades, and nettles, and numerous plants cultivated for their ornamental flowers, and fruit. Currently, new researchers that they found the new pesticides by developing from plants of Solanaceae e.g. glycoalkaloids, terpenoids, alkaloids, organic acids and alcohols, which effective for use in plant protection from pesticides (disturb the level of biological organization). The accumulation and receiving of several UV-absorbing phenolic compounds that are phenylpropanoid derivatives to play a significant role in UV-B (ultraviolet B- Radiation) screening and less insect herbivory in plants. Solanum genus of about 2,300 species of flowering plants in the nightshade family (Solanaceae). The active principle being solanine and solamargine, which can cause convulsions and death if taken high in large doses, active principal include phenolic and flavonoids contents (Chlorogenic acid, vanillin, p-coumaric acid, caffeic acid, 4-hydroxy -3-methoxy cinnamaldehyde, ferulic acid, neochlorogenic acid) compounds that they responsible for the antimicrobial activity.