Inflammation plays an important role in coronary artery disease development and several processes involved in the sequence of events that follow the obstruction of an epicardial coronary artery in the context of STEMI, including thrombus composition, endothelial function, post-infarction myocardial function . Colchicine is a drug with well-known anti-inflammatory properties, shown to be safe in various settings of cardiovascular disease. The results of previous randomized trial suggested that treatment with colchicine in patients with STEMI undergoing primary percutaneous coronary intervention is associated with smaller infarct size. This effect was accompanied by a substantial treatment-related difference in markers of post–myocardial infarction inflammatory response, namely neutrophil count and C-reactive protein. Our aim of study aimed to evaluate the efficacy of colchicine in the prevention of bare-metal stent restenosis and target vessel revascularization in patients with BMS plus colchicine compared to BMS alone and DES.