Substance abuse is a major health concern and is becoming a public health issue. Нe cognitive functions the brain is Dوٴected by substance induced vascular abnormalities and related organ function problems. Substance induced cerebrovascular maladaptation alters cognitive and behavioral responses. A study indicated that blood floZ into brain was reduced in subjects with cognitive problems and a stroke is common among amphetamine and amphetamine like-stimulant abusers. One of the substances reported to have stimulatory response related to amphetamines and widely consumed in east African countries including Ethiopia is Catha edulis Forsk, commonly called Khat. Its health and socio-economic burdens are becoming public problems.