The heart is a highly organized tissue and consists of ventricular or atrial cardiomyocytes, pacemaker cells, Purkinje cells, vasculature, and connective tissue. It exerts striking responses to a series of genetic and environmental factors inorder to maintain its contractile function. Disruption in such responses, mediated by signalling pathways, promotes cardiac dysfunction leading to cardiomyopathy. Cardiomyocytes are the contracting cell in the heart, that exist in a three-dimensional network of endothelial cells, vascular smooth muscle, and plenty of fibroblast as well as a transcient population of immune cells. The contraction of individual cardiomyocytes is coordinated electrochemically by gap junctions, and the connection of these cardiomyocytes with the ECM transduces force and directs the overall contraction of the heart.