The generation of new neurons is not restricted to embryonic development but continues throughout life in the subgranular zone of the dentate gyrus. Нe functional integration of adult-born neurons into the hippocampal circuitry confers a unique form of plasticity that contributes to learning and memory processes as well as mood regulation. Нis neurogenic process is finel\ modulated by extrinsic factors promoting or inhibiting its progression rate and timing. NeuroinflDmmDtion is a hallmark of several pathological conditions underlying neurogenesis dysregulation and deficits on hippocampaldependent tasks. Ðerefore, one of the main interests in the neurogenesis field is to understand how neuroinflDmmDtion modifies the neurogenic process. Since a pioneering report that used a single systemic LPS administration as a model for inducing brain inflDmmDtion, it has been well accepted that the inflDmmDtor\ response sets a non-permissive neurogenic microenvironment in the brain that leads to a reduced number of adult-born neurons.