The diagnosis of NPC should be based on clinical examination, the Magnetic Resonance Imaging (MRI) or CT scan of the nasopharynx in addition to bone scan and CT of the chest and abdomen for distant extent in locally advanced disease. The confirmation of the diagnosis is obtained by naso-endoscopy with nasopharyngeal biopsy [4]. Therapeutically, management strategy depends mainly on the stage of the disease. Radiotherapy is the mainstay of radical treatment for localized disease because of the radio-sensitivity of these tumors, with better control by using Intensity Modulated Radiotherapy (IMRT) and concomitant cisplatinbased chemotherapy for locally advanced disease. Palliative chemotherapy remains the basis of treatment for metastatic stage. With this work we report the experience of a Moroccan unit at Hassan II University Hospital, in Fes, Morocco. The aim of this work is to describe epidemiological, clinical, preclinical, therapeutic and prognostic aspects of this disease in Moroccan patients and discuss our results in comparison with literature.