Dopamine hypothesis is the most developed hypothesis among others and becomes the basis of many rational drug therapies. In schizophrenia, extracellular dopamine is increased. Нese dopamine levels play an important role in changing diوٴerent feelings and moods. If dopamine levels are unbalanced, excessive or deficient, patients can experience positive symptoms and negative symptoms. Reduced dopamine in the mesocortical pathway can cause negative symptoms and cognitive impairment. When dopamine increases in the mesolimbic pathway, it can cause positive symptoms of schizophrenia. Clinical examinations that describe the psychopathological condition of patients are based on changes in Positive and Negative Syndrome Scale (PANSS) scores. PANSS is used to measure the success of treatment. Research on dopamine as the main cause of schizophrenia has not revealed the mechanism of schizophrenia as a whole, so other research needs to be done in an eوٴort to explain the mechanism. Recent studies of inflammator\ response activity in schizophrenia have aberrant cytokines, especially proinflammator\ cytokines interleukin (IL)-6 in peripheral blood or cerebrospinal fluid in schizophrenic patients. Data from 62 studies involving a total sample of 2298 schizophrenic patients and 1,858 healthy volunteers, showed an increase in IL-6 in schizophrenic patients.