As one of the common malignant tumors in the world, the esophageal carcinoma can be grouped in two categories based on its pathological features, i.e. esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. The morbidity and mortality of ESCC in China ranks first in the world while such category accounts for more than 90% of all pathological patterns, featuring the easy metastasis and invasion, as well as recurrence. The major therapies used for the ESCC currently are surgery in combination with neoadjuvant chemoradiation. Thus it may be of great significance if the effective therapeutic targets might be identified based on understanding the mechanism of ESCC at the molecular level. MicroRNAs (miRNAs) are a group of small non-coding RNAs which may regulate the gene expression at post-transcriptional level. As the important regulator in cell pathway, miRNA may act as the oncogene, antioncogene or transfer regulator. In the prior experiment, we had determined that miR-483-5p would be up-regulated in ESCC which might facilitate the occurrence of such cancer.