Neurofunctional Recovery in Chronic Stroke
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Stroke is the most common non communicable disease which leads to serious disability. One of the common deficits following stroke is upper limb motor impairment & motor control dysfunction which can significantly impact on activities of daily living and performance. Variability in the nature and extent of the upper limb is well accepted & reported. A large number of upper limbs neuromotor approaches are currently available but CIMT (Constraint Induced Movement therapy) has proven to be silver bullet to regain upper extremity function especially in chronic strokes. It is a known fact that recovery of hand motor function is usually incomplete, 2/3 of patients still suffer from profoundly impaired dexterity, which significantly impacts the individual’s disability and activities of daily living. rTMS (repetitive transcranial magnetic stimulation) is a non-invasive, effective, and a painless therapeutic stimulation to modulate cortical excitability of motor area and has the potential to improve dexterity of affected hand after stroke. High frequency rTMS over the primary motor cortex (M1) in the affected hemisphere could improve motor learning performance in patients with chronic stroke and have a positive, long-term effect on motor recovery in acute and subacute patients with stroke. The proof of principle studies has demonstrated that the inhibitory rTMS applied over the contralesional M1 or the facilitatory rTMS applied over the M1 may improve dexterity of the affected hand following stroke.