MIT Manus robotic studies, robotic rehabilitation has been largely studied to restore loss of motor function on upper limb paresis. Multiple studies suggested that robot-assisted training integrated into a multidisciplinary team resulted in reduction of motor impairment compared to usual rehabilitation. Although stroke is the leading cause of disability and considering that 20% of patients present an upper limb deficLt, many other studies showed robotic rehabilitation applied to upper limb in many other neurological diseases. In fact, the scLentLfic literature about Multiple sclerosis and Spinal cord injury described a good recovery of arm motor function using technology, considering the enhancement of neural plasticity. However, robotic rehabilitation is eوٴectLve considering some factors, such as the frequency and intensity of training sessions, the use of feedback and the possibility of using assist-as-needed algorithms, that allows the right quantity of assistance based on the patient’s motor performance. Several studies on the eÙ¹cacy of robot-mediated rehabilitation on upper limb paresis in stroke have shown an increase in motor function, especially in the segment of the limb treated with robots in acute, subacute and chronic patients.