Regarding squamous cell carcinoma in non-endemic areas, smoking and alcohol are the most incriminated risk factors. The diagnosis of NPC should be based on clinical examination, the Magnetic Resonance Imaging (MRI) or CT scan of the nasopharynx in addition to bone scan and CT of the chest and abdomen for distant extent in locally advanced disease. The confirmation of the diagnosis is obtained by naso-endoscopy with nasopharyngeal biopsy. Therapeutically, management strategy depends mainly on the stage of the disease. Radiotherapy is the mainstay of radical treatment for localized disease because of the radio-sensitivity of these tumors, with better control by using Intensity Modulated Radiotherapy (IMRT) and concomitant cisplatinbased chemotherapy for locally advanced disease. Palliative chemotherapy remains the basis of treatment for metastatic stage.