Parotid Melanoma of Unknown Primary Site
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The origin of parotid melanoma was still a topic of discussion. The development of this type of cancer in the parotid is due to the fact that the parotid gland contains melanoblasts and melanin in the ductal and acinar cells and they also noted that the localization of melanomas were not in the lymph nodes. Takeda also demonstrated in an autopsy case the presence of melanocytes in the basal and supra-basal layers of the parotid, which explains the appearance of melanoma at this level. Therapeutically, for resectable tumors, superficial parotidectomy with cervical dissection remains the standard treatment. Radical parotidectomy has not shown any survival benefit. Adjuvant radiation therapy is not a standard; indicated in high-risk patients for local control purposes.