In the development of placental insufficiency there are several interrelated pathogenetic mechanisms: insufficiency of cytotrophoblast invasion, pathological changes in utero-placental circulation, violation of fetoplacental blood flow, lesion of the placental barrier with violation of its permeability, reduction of compensatory and adaptive reactions in the mother-placenta system-fetus. It should be emphasized that the formation of persistent disturbances of the function of the placenta is preceded by a violation of hemocirculation in the fetoplacental-fetal vessels, primarily due to increased pressure and vascular resistance. Any treatment of PI is exclusively pathogenic or symptomatic, and the potential of medication to the fetus is limited to the morphofunctional capacity of the placenta. Pharmacotherapy PI includes the following groups of drugs.