ST-segment elevation is associated with several conditions including acute myocardial infarction, myocarditis, pericarditis, early repolarization, electrolyte imbalance. Electrocardiogram (ECG) findings in acute coronary syndromes (ACS) are predictive for the responsible artery and lesions. In patients with ST- segment elevation in the anterior precordial leads especially indicates left anterior descending (LAD) coronary artery occlusion and elevation in the inferior and/or lateral precordial leads especially indicates left circumflex artery (LCX) and/or right coronary artery (RCA) occlusion. However ST-segment elevation in the inferior leads has also been described especially at the distal part of LAD occlusion. In our case, we detected ST-segment elevation in the inferior leads associated with acute LAD stent thrombosis, following primer percutaneous coronary intervention (PCI) of LAD proximal occlusion which had presented with anterior myocardial infarction.