The following disquisition is designed to be an exploration of the controversies, contentions, and consternations with regard to the efficacy and potential of a newly devised CAM approach which entails modulating the endocannabinoid system and is considered to be a useful technique for the treatment of obesity and diabetes. By necessity, this exploration becomes rather convoluted because in the year 2006 traditional medicine took a shot at incorporating this CAM approach into their world-view by attempting to integrate their synthetic, single molecule paradigm into a system of incredible molecular diversity. Although the attempt failed dramatically and resulted in a large number of major depressive episodes as well as two suicides, the endeavor provided some valuable knowledge applicable to the field of bimolecular psychology.