Among the different cardiovascular components, the highlights this year were mainly related to vascular as well valvular heart diseases, walking home with a clear safety and efficacy message on the relatively new choice of TAVR (TAVI) as an alternative to the traditional intermediate risky open heart aortic valve replacement. Furthermore, the clinical utilization of PCSK9 as a new therapy to lowering LDL cholesterol has been remarkably shown by FOURIER trial investigators to be feasible (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk). Interestingly, the word “Fourier” is the name of French mathematician and physicist (Joseph Fourier 1768-1830), who developed Fourier analysis and studied the conduction of Heat in relation to Time domain. Perhaps a friendly coincidence to remember that “time” is an important factor in the management of LDL cholesterol as a risk factor for coronary artery disease (CAD).